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TITLE:
Ramachandran revisited: Conformational energetics and conformation
dependent peptide geometries
SPEAKER:
Professor P. Andrew Karplus,
TIME: Thursday Sept. 14, 2006 at 4:00 PM
PLACE: George P. Williams, Jr. Lecture Hall, (Olin 101)
Refreshments will be served at 3:30 PM in the lounge.
All interested persons are cordially invited to attend.
Accurately predicting protein folding based on sequence is a major
unsolved problem in biophysics and success will be based on a detailed
understanding of the conformational energetics of natural polypeptides
in water. Dr. Karplus will present observations of conformational
details seen in high resolution protein structures that show variation
in covalent geometry and give insight into the energetics of folded
proteins. Much of the material is based on his paper "Experimentally
Observed Conformation Dependent Geometry and Hidden Strain in Proteins" in
Protein Science 5, 1406-1420 (1996).
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 100 Olin Physical Laboratory, 7507 Reynolda Station Wake Forest University Winston-Salem, NC 27109-7507 Phone: (336) 758-5337, FAX: (336) 758-6142 E-mail: wfuphys@wfu.edu |
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