DEPARTMENT OF CHEMISTRY

FACULTY ACTIVITIES REPORT

JULY 1, 1999-JUNE 30, 2000


 

 

 

I. Publications, Performances, Exhibits

 

Bierbach, Uli

 

N. Farrell, Y. Qu, U. Bierbach, M. Valsecchi and E. Menta: “Structure-activity relationships within dinuclear and trinuclear platinum phase I clinical anticancer agents.” In 30 Years of CisplatinChemistry and Biochemistry of a Leading Anticancer Drug. B. Lippert, ed.; Verlag HCA, Basel, Switzerland, 1999.

 

U. Bierbach, Y. Qu, T. W. Hambley, J. Peroutka, H. L. Nguyen, M. Doedee and N. Farrell: Synthesis, structure, biological activity, and DNA binding of platinum(II) complexes of the type trans-[PtCl2(NH3)L] (L = planar nitrogen base). Effect of L and cis/trans isomerism on sequence specificity and unwinding properties observed in globally platinated DNA. Inorg. Chem., 38:3535 (1999).

 

Colyer, Christa L.

 

C.L. Colyer, “Death in a Viennese Maternity Ward.  Childbed Fever – A Nineteenth-Century Mystery,” Journal of College Science Teaching, Vol. XXIX, No. 5:  297-300, 2000.

 

J. Li, P. Thibault, N.H. Bings, C.D. Skinner, C. Wang, C.L. Colyer, and D.J. Harrison, Integration of microfabricated devices to capillary electrophoresis-electrospray mass spectrometry using a low dead volume connection:  Application to rapid analyses of proteolytic digests.  Anal. Chem. 71: 3036-3045, 1999.

 

N.H. Bings, C. Wang, C.D. Skinner, C.L. Colyer, P. Thibault, and D.J. Harrison, Microfluidic devices connected to glass capillaries with minimal dead volume.  Anal. Chem.  71: 3292-3296, 1999.

 

E.D. Moody, P.J. Viskari, and C.L. Colyer, Non-covalent labeling of human serum albumin with indocyanine green:  A study by capillary electrophoresis with diode laser-induced fluorescence detection.  J. Chromatogr. B  729: 55-64, 1999.

 

Haefner, Steven C.

 

Synthesis, Reactivity, and Structure of (m-acetamidato)hexakis(acetonitrilo)dimolyb-denum(II)tris(tetrafluoroborate) and Derivatives.    F. A. Cotton, L. M. Daniels, S. C. Haefner and F. E. Kühn,  Inorg. Chim. Acta , 1999, 287, 159.

 

F. A. Cotton, L. M. Daniels, S. C. Haefner and A. P. Sattelberger, Metal-Metal Multiply-Bonded Complexes of Technetium. 8.  Structural and Spectroscopic Characterization of Alpha and Beta Isomers of Tc2Cl4(dppe)2, Inorg. Chim. Acta , 1999, 288, 69.

 

Hinze, Willie L.

 

F. H. Quina and W. L. Hinze,  “Surfactant-Mediated Cloud Point Extractions:  An Environmentally Benign Alternative Separation Approach”, Industrial & Engineering Chemistry Research, 38 (#11), 1999, 4150 – 4168.

 

W. L. Hinze, W. Hu, F. H. Quina, and I. U. Mohammadzai, “Bile Acid/Salt Surfactant Systems:  General Properties and Survey of Analytical Applications”, in Bile Acid/Salt Surfactant Systems (W. L. Hinze, Ed.), JAI Press, Inc.:  Stamford, CT, 2000, 1 – 50.

 

W.L. Hinze, Edited Monograph entitled “Bile Acid/Salt Surfactant Systems”, JAI Press, Inc., Stamford, CT, April 2000, 346 pp [part of the JAI Press Series on Organized Assemblies in Chemical Analysis]

 

Jones, Bradley T.

 

A. Salido, C.L. Sanford, B.T. Jones, "Determination of Lead in blood with ammonium pyrrolidine dithiocarbamate followed by W-coil atomic absorption spectrometry," Spectrochim. Acta Part B, 1999, 54, 1167-1176.

 

A. Salido, B.T. Jones, "Simultaneous determination of Cu, Cd, and Pb in drinking water using W-coil AAS," Talanta, 1999, 50, 649-659.

 

J.D. Batchelor, B.T. Jones, "Determination of the Scoville Heat value for Hot Sauces and Chilies:  An HPLC Experiment," J. Chem. Ed., 2000, 77, 266-267.

 

King, Angela Glisan

 

Angela G. King and Yue-Ling Wong, Utilizing Technological Tools in General Chemistry, in Interactive Learnings, David G. Brown, editor, Anker Publishing Company, Inc., Boston, MA; 2000.

 

King, S. Bruce

 

Yasaki, G.; Xu, Y.; King, S.B. “An Efficient Synthesis of 15N-Hydroxyurea,” Synthetic Communications, 2000, 30, 2041-2047

 

Jenkins, N.E.; Ware, Jr., R.W.; Atkinson, R.N., King, S.B. “Generation of Acyl Nitroso Compounds by the Oxidation of N-Acyl Hydroxylamines with the Dess Martin Periodinane,” Synthetic Communications, 2000, 30, 947-953.

 

Rupon, J.W.; Domingo, S.R.; Smith, S.V.; Gummadi, B.K.; Shields, H.; Ballas, S.K.; King, S.B.; Kim-Shapiro, D.B. “The Reactions of Myoglobin, Normal Adult Hemoglobin, Sickle Cell Hemoglobin and Hemin with Hydroxyurea,” Biophysical Chem. 2000, 84, 1-11.

 

Atkinson, R.N.; King, S.B. “Guanidine Substituted Imidazoles as Inhibitors of Nitric Oxide Synthase,” Bioorganic and Medicinal Chemistry Letters, 1999, 9, 2953-2958.

 

Kim-Shapiro, D.B.; King, S.B.; Shields, H.; Kolibash, C.P.; Gravatt, L.; Ballas, S.K. “The Reaction of Deoxy-Sickle Cell Hemoglobin with Hydroxyurea,” Biochimica et Biophysica Acta, 1999, 1428, 381-387.

 

Ware, Jr., R.W.; King, S.B. “N-Phosphinoylnitroso Compounds:  New Asymmetric N-O Heterodienophiles and Nitroxyl Delivery Agents,” J. Am. Chem. Soc. 1999, 121, 6769-6770.

 

 

Kondepudi, Dilip

 

D.K. Kondepudi, T. Buhse, D. Durand, J. Laudadio, S. Spilker, "Chiral Symmetry Breaking in Crystallization: The Role of Convection" Phys. Rev. Lett. 84 (2000) 4405-4408

 

D.K. Kondepudi, Kouichi Asakura, Akihito Ikumo, Kazuyuki Kurihara and Shuichi Osanai,"Random Chiral Asymmetry Generation by Chiral Autocatalysis in Far-From-Equilibrium Reaction Systems"  J. Phys. Chem. A104 (2000) 2689-2694.

 

Lachgar, Abdou

 

Ekaterina V. Anokhina, Cynthia S. Day, and Abdessadek Lachgar, "Towards the Design of Open-Framework Cluster materials: A New Layered Niobium Oxochloride Related to Hexagonal Bronzes", Angew. Chem., 39: (6) 1047, 2000.

 

A. Nägele, E. Anokhina, J. Sitar, H.-J. Meyer, and A. Lachgar ”Synthesis and Crystal Structures of ATi[Nb6Cl18] Compounds (A = K, Rb, Cs, In, Tl), Z. Naturforsch. B 55: (2) 139-144, 2000.

 

X. Tang, A. Jones, B.J. Gross, J.L. Yarger, and A. Lachgar,Synthesis, Crystal Structure, NMR Studies, and Thermal Stability of Mixed Iron-Indium Phosphates with Quasi One-dimensional Frameworks” Inorg. Chem., 1999, 38(26), 6032-6038.

 

Ekaterina V. Anokhina, Michael W. Essig, Cynthia S. Day, and Abdessadek Lachgar "Ti2Nb6O12: A Novel Niobium Oxide Cluster Compound with “Chevrel Phase” Intercluster Connectivity Type", J. Am. Chem. Soc. 1999, 121, 6827-6833.

 

Narula PM, Day CS, Lachgar A, Pennington WT, Noftle RE, “Characterization and crystal structures of some fluorinated imides”, Polyhedron, 1999 18: (12) 1751-1759.

 

Nagele A, Gibson K, Lachgar A, Meyer HJ “Synthesis, structure, and decomposition of (NH4)2[Mo6Cl14]•H2O”, Z. Anorg Allgem Chem. 1999, 625: (5) 799-802.

 

E.V. Anokhina, M.E. Essig, C.S. Day, and A. Lachgar “Open-Framework Engineering in Niobium Oxochloride Cluster Chemistry” IUCr (1999), Acta Cryst. A55 supplement, P11.OD.002.

 

 

Manderville, Richard A.

 

Gillman, I. G.; Clark, T. N.; Manderville, R. A. “Oxidation of Ochratoxin A by an Fe-Porphyrin System: Model for Enzymatic Activation and DNA Cleavage.  Chem. Res. Toxicol.  1999, 12, 1066-1076.

 

Melvin, M. S.; Ferguson, D. C.; Lindquist, N.; Manderville, R. A. “DNA Binding by 4-Methoxypyrrolic Natural Products.  Preference for Intercalation at AT Sites by Tambjamine E and Prodigiosin” J. Org. Chem., 1999, 64, 6861-6869.

 

Welker, Mark E.

 

John J. Chapman, Cynthia S. Day, and Mark E. Welker*, Synthesis and Enantioselective Diels-Alder Reactions of Optically Active Cobalt(III)Salen-1,3-Butadien-2-yl Complexes. Organometallics, 2000, 1615.

 

Allison L. Hurley, Mark E. Welker*, and Cynthia S. Day, Reactions of Transition-Metal h1-Propargyl Complexes with Sulfur Dioxide and Sulfur Trioxide.  Transition-Metal Carbon Bond cleaving Reactions of the Cycloadducts Which Yield 1,2-Oxathiole-2-Oxides and –2,2-Dioxides. J. Organometal. Chem., 2000, 598, 150.

 

Ginger J. Lohr and Mark E. Welker*, Reactions of Cobaloximes with Vinyl Allenes as a Route to 1-Cobaloxime Substituted 1,3-Dienyl Complexes. Invited contribution to a Topical Volume of Inorganica Chimica Acta on Metals in Organic Chemistry.  Inorg. Chim. Acta., 1999, 296, 13. 

 

N. Ariane Vinson, Cynthia S. Day, Mark E. Welker*, Ilia Guzei, and Arnold L. Rheingold. Transition-Metal Mediated 2-Alkylidene Cyclobutanone Synthesis. Organometallics, 1999, 18, 1824.

 

II. Papers and Presentations

 

Colyer, Christa L.

 

C.L. Colyer, Labeling made easy for capillary electrophoresis with laser-induced fluorescence detection. (Invited seminar) Department of Chemistry, Virginia Polytechnic Institute & State University, Blacksburg, VA:  March 31, 2000.

 

C.L. Colyer, Capillary Electrophoresis with Laser-Induced Fluorescence Detection: Labeling Made Easy. (Invited seminar) Department of Chemistry, Furman University, Greenville, SC:  Nov. 03, 1999.

 

E.D. Moody, P.J. Viskari, and C.L. Colyer,  Non-covalent labeling of proteins in capillary electrophoresis with laser-induced fluorescence detection. (Contributed seminar) 51st ACS Southeast Regional Meeting, Knoxville, TN: Oct. 17-20, 1999.

 

C.L. Colyer,  Computer enhanced learning at Wake Forest University. (Invited seminar) Chatham College, Pittsburgh, PA:  Aug. 23, 1999.

 

 

Haefner, Steven C.

 

S. C. Haefner, E. Gilmore, P. Hodes, and C. S. Day, Synthesis and Reactivity of Homoleptic Dimethylformamide Complexes Possessing a Metal-metal Multiple Bond. Gordon Research Conference on Inorganic Chemistry, Newport, RI, 7/99

 

S. C. Haefner, E. Gilmore, P. Hodes, and C. S. Day, Synthesis and Reactivity of Homoleptic Dimethylformamide Complexes Possessing a Metal-metal Multiple Bond. SERMACS-99, Southeast Regional Meeting of the American Chemical Society, Knoxville, TN, 10/99

 

S. C. Haefner, E. Gilmore, P. Hodes, Susanne Monnier, and C. S. Day, New Directions in the Chemistry of Solvated Metal-Metal Multiple Bonds. Contemporary Inorganic Chemistry II. Cotton, College Station, TX, 3/00.

 

Hinze, Willie L.

 

W.L. Hinze,  “Cloud Point Preconcentration & Gas Chromatographic Analysis of Substituted Benzenes”, Gulf Coast Conference, Galveston, Texas, September 14, 1999.

 

W.L. Hinze, “Surfactant-Mediated Cloud Point Extractions”, 11th International Conference on Partitioning in Aqueous Two-Phase Systems, Gulf Shores, Alabama, July 1, 1999.

 

W.L. Hinze, “Cloud Point Preconcentration and Gas Chromatographic Determination of BTEX Mixtures”, Eastern Analytical Symposium, Somerset, New Jersey, November 17, 1999.

 

King, S. Bruce

 

King, S.B. "Hemoglobin Mediated Nitric Oxide Release from Hydroxyurea," American Heart Association 2000 Research Symposium, Dallas, TX, May 6, 2000.

 

King, S.B.; Kim-Shapiro, D.B.; Shields, H.; Rupon, J.; Gravatt, L.; Domingo, S.; Smith, S. “A Role for Nitric Oxide in the Nitrosylation of Sickle Cell Hemoglobin,” 6th Annual Meeting of the Oxygen Society, New Orleans, LA, November 18-22, 1999.

 

King, S.B.; Rupon, J.; Kim-Shapiro, D.B; Shields, H.; Domingo, S.; Smith, S. “Reactions of Hydroxyurea with Hemoglobin,” Abstract of Papers, 51st Southeast Regional Meeting of the American Chemical Society, Knoxville, TN, American Chemical Society, Washington, D.C. 1999, MEDI 319.

 

King, S.B., Chemistry Department Seminar, University of Toledo, January 20, 2000

 

King, S.B., Chemistry Department Seminar, Wayne State University, January 19, 2000

 

Kondepudi, Dilip

 

D.K. Kondepudi, "Spontaneous Generation and Propagation of Chiral Asymmetry" Chemistry Colloquium, Vanderbilt University 24 April, 2000.

 

D.K. Kondepudi, "Modern Thermodynamics in the Undergraduate Curriculum Using Mathematica" Chemical Education Division National Meeting of the American Chemical Society San Francisco, USA 26-31, March, 2000

 

D.K. Kondepudi, "Chiral Autocatalysis and Selectivity in the Vicinity of Solid Surfaces" Symposium on Physical Chemistry of Chirality National Meeting of the American Chemical Society San Francisco, USA 26-31, March, 2000.

 

D.K. Kondepudi, "Stochastic Behavior in Chirally Autocatalytic Systems" International Symposium on Chaos and Order Nara, Japan 17-20 March, 2000

 

D.K. Kondepudi, "The Enigma of Asymmetry" International Conference on the Unity of Sciences Seoul, Korea. 9-13 February, 2000.

 

D.K. Kondepudi,"Nonequilibrium Thermodynamics and the Definition of an Event" Symposium: "Qu'est-ce qu'un événement ? (What is an Event)" Brussels, Belgium 30 Nov. - 2 Dec. 1999.

 

D.K. Kondepudi,"Chiral Asymmetry Through Stirred Crystallization: Chiral Selection Near Solid Chiral Surfaces" American Chemical Society, Regional Meeting. Knoxville, TN. 17-21 October, 1999.

 

Lachgar, Abdou

 

E.V. Anokhina, M.E. Essig, C.S. Day, and A. Lachgar “Open-Framework Engineering in Niobium Oxochloride Cluster Chemistry” Congress of the International Union of Crystallography, Glasgow, Scotland, August 5-13, 1999

 

E.V. Anokhina and A. Lachgar “Application of the mixed-ligand strategy to the preparation of low-dimensional cluster based materials” The 8th International meeting on the physics and chemistry of solids, Tetouan, Morocco, October 22-27, 1999

 

A. Lachgar “Low-dimensional niobium oxochloride cluster materials”,  Department of Physics, Wake Forest University, September 23, 1999

 

A. LachgarFramework Engineering in Niobium Oxochloride Cluster Chemistry”, Department of Chemistry, University of North Carolina at Chapel Hill, September 28, 1999

 

E.V. Anokhina, C. S. Day, and A. Lachgar “Structure and Properties of a New Reduced-Niobium Oxochloride Based on Triangular Nb3 clusters”, ACS National meeting, March 26-31, 2000, San Francisco

 

E.V. Anokhina, C. S. Day, and A. Lachgar “A Layered Niobium Cluster Oxochloride with a Novel Framework Topology: Cs2Ti3Nb12Cl27O8”, ACS National meeting, March 26-31, 2000, San Francisco

 

Manderville, Richard A.

 

R.A. Manderville, Invited Seminar, “DNA Cleavage by Natural Products forming Dinuclear Copper Complexes” East Carolina University, Greenville, N.C., October 8, 1999.

 

R.A. Manderville, Invited Seminar, “DNA Cleavage by 4-Methoxypyrrolic Natural Products” Davidson College, Davidson, N.C. November 19, 1999.

 

R.A. Manderville, Invited Seminar, “DNA Cleavage by Copper-Bound Natural Products” UNC-Greensboro, N.C. February 23, 2000.

 

R.A. Manderville, Invited Seminar, “DNA Cleavage by Copper-Bound Natural Products” University of Missouri, Columbia, MO. April 10, 2000.

 

R.A. Manderville, Invited Seminar, “DNA Cleavage by Copper-Bound Natural Products” Carnegie Mellon University, Pittsburg, PA. April 18, 2000.

 

M.S. Melvin, D. C. Ferguson, R.A. Manderville, “Synthesis and DNA Interactions of 4-Methoxy Bipyrrole Natural Products” SERMACS-99, Knoxville, Tennessee, October 19, 1999.

 

R.A. Manderville, I.G. Gillman, T.N. Clark, W. Calcutt,  R.E. Noftle, “Electrochemical- and Fe-porphyrin-mediated Oxidation of Ochratoxin A: Model for DNA Cleavage and Bioactivation” 9th North American International Society for the Study of Xenobiotics (ISSX) Meeting, Nashville, Tennessee, October 28, 1999.

 

Welker, Mark E.

 

M.E. Welker, Departmental Seminar, Guilford College, Greensboro, NC 12/3/99.

 

M.E. Welker, Seminar for Eastman Chemical Company, Kingsport, TN 11/16/99.

 

M.E. Welker, National American Chemical Society Meeting, San Francisco, CA, 3/24/2000.

 

III. Editorships, Offices, and Consultancies

Hinze, Willie L.

 

Member of the Editorial Boards of (1) Analytical Letters, (2) Journal of Liquid Chromatography, and (3) Talanta

 

Jones, Bradley T.

 

External Reviewer for the Chemistry Graduate Program at Western Carolina University

Panel Review  Board for the EPA

Consultant for Leeman Labs, Inc. Hudson, NH (approximately 10 hr/month)

 

King, Angela Glisan

 

Member Editorial Board, Interactive Multimedia Electronic Jounal of Computer-Enhanced Learning, 1997-present.

Secretary, Piedmont Triad Association for Women in Science (Fall 1999-present)

Consultant for ICCEL, < 10 hours/year

 

Kondepudi, Dilip

 

Editorial Board of the journal "Chirality"

 

Noftle, Ronald E.

 

Member, Executive Committee, Division of Fluorine Chemistry, Amer. Chem. Soc.

Alternate Councilor, Division of Fluorine Chemistry, Amer. Chem. Soc.

Visiting Associate, Committee on Professional Training, Amer. Chem. Soc.

National Science Foundation, Review Panel on CCLI Grants, Wash., D.C., July 1999, 3.5 days.

Consultant Marshallton Research Laboratories, about one-half hour per month

 

IV. External Grants Received

Jones, Bradley T.

 

B.T. Jones, Leeman Labs, Inc. “Tungsten Coil Atomic Spectrometry.” 2000, $21,000.

 

B.T. Jones, SpectroAnalytical Instruments, “Xray Fluorescence Spectrometer,” 2000, $18,000.

 

King, S. Bruce

 

S.B. King, Dreyfus Foundation Teacher Scholar Award, “Bio-organic Chemistry of N-Hydroxyureas and Related Compounds,” 2000, $60,000.

 

S.B. King, NIH, “Reactions of Hydroxyurea with Sickle Cell Hemoglobin,” 2000, $475,000.

 

Kondepudi, Dilip

 

D.K. Kondepudi, Japan Society for the Promotion of Science, “6-month fellowship,” 2000, $30,000.

 

Lachgar, Abdou

 

A. Lachgar, NSF, “The mixed ligand approach to the preparation of low-dimensional cluster materials,” 2000, $343,225.

 

Manderville, Richar A.

 

R.A. Manderville, NIH, “DNA Damage and Mutagenicity of Ochratoxin A,” 2000, $691,596.

 

Noftle, Ronald E.

 

R.E. Noftle, NIH, “Synthesis and Electrochemistry of Thiophene Imides,” 2000, $122,982.

 

Swofford, Robert L.

 

R.L. Swofford, NC Dept of Public Instruction, “1999 Technology Literacy Challenge Grant,” 1999, $55,000.

 

R.L. Swofford, Eisenhower Foundation, US Dept. of Ed., “Using the TIMSS Report to Guide Curricular Realignment,” $30,000.

 

R.L. Swofford, NC Math and Science Education Network, Eisenhower Foundation, US Dept. of Ed., “Special Grant for Teacher Professional Development,” 2000, $5000.

 

Welker, Mark E.

 

M.E. Welker, NIH, "Synthesis of Anti-HIV Agents that Target Retroviral Zinc Fingers," 2000, $147,320.