SUMMARY OF WFU CHEMISTRY FACULTY INFORMATION FORMS

FOR

Reporting Professional Activities

 

Reynolda Campus

2003-2004

I. Publications, Performances, Exhibits

II. Papers and Presentations

III. Editorships, Offices, and Consultancies

IV. External Grants Received

 

I.  Publications, Performances, Exhibits  

 

Bierbach, Ulrich

 

M. C. Ackley, C. G. Barry, A. M. Mounds, M. C. Farmer, B.-E. Springer, C. S. Day, M. W. Wright, S. J. Berners-Price, S. M. Hess, U. Bierbach: Structure-activity relationships in platinum-acridinylthiourea conjugates: effect of the thiourea nonleaving group on drug stability, nucleobase affinity, and in vitro cytotoxicity. J. Biol. Inorg. Chem. (2004) published online April 6, 2004, DOI: 10.1007/s00775-004-0541-4.

 

H. Baruah, C. S. Day, M. W. Wright and U. Bierbach: Metal-intercalator-mediated self-association and one-dimensional aggregation in the structure of the excised major DNA adduct of a platinum-acridine agent. J. Am. Chem. Soc. 126, 4492-4493 (2004).

 

U. Bierbach: Annual Review of Biophysics and Biomolecular Structure, Volume 32.  Edited by Robert M. Stoud (University of California, San Francisco), Wilma K. Olson (Rutgers University), and Michael P. Sheetz (Columbia University).  Annual Reviews: Palo Alto, CA. 2003. xvi + 534 pp. $80.00 print version for individuals, $180 print version for institutions. ISBN 0-8243-1832-3. (Book Review) J. Am. Chem. Soc. 126, 4742-4743 (2004).

 

H. Baruah and U. Bierbach: Biophysical characterization and molecular modeling of the coordinative-intercalative DNA monoadduct of a platinum-acridinylthiourea agent in a site-specifically modified dodecamer. J. Biol. Inorg. Chem. 9, 335-344 (2004).

 

C. G. Barry, H. Baruah and U. Bierbach: Unprecedented Monofunctional Metalation of Adenine Nucleobase in Guanine and Thymine Containing Dinucleotide Sequences by a Cytotoxic Platinum-Acridine Hybrid Agent. J. Am. Chem. Soc. 125, 9629-9637 (2003).

 

H. Baruah and U. Bierbach: Unusual intercalation of acridin-9-ylthiourea into the 5'-GA/TC DNA base step from the minor groove: Implications for the covalent DNA adduct profile of a novel platinum-intercalator conjugate. Nucleic Acids Res. 31, 4138-4146 (2003).

 

Jones, Bradley

 

H.L. Peters, X. Hou, B.T. Jones, "Multi-Analyte Calibration Curve for High-Performance Liquid Chromatography with an Inductively Coupled Plasma Carbon Emission Detector,” Applied Spectroscopy, 2003, 57, 1162-1166.

 

X. Hou, Y. He, B.T. Jones, “Recent Advances in Portable X-Ray Fluorescence Spectrometry,” Appl. Spectrosc. Rev., 2004, 39, 1-25.

 

H.L. Peters, A.C. Davis, B.T. Jones, “Enantiomeric separations of amino acids with inductively coupled plasma carbon emission detection,” Microchem. J., 2004, 76, 85–89.

 

R. Zhao, R.P. Planalp, R. Ma, B.T. Greene, B.T. Jones, M.W. Brechbiel, F.M. Torti, S.V. Torti, “Role of Iron and Zinc Chelation in Apoptosis Mediated by Tachpyridine, an Anti-Cancer Iron Chelator,” Biochem. Pharmacol., 2004, 67, 1677–1688.

 

Invited lecture at Salem College, The Analytical Methods of Sherlock Holmes, October 22, 2003.

 

Invited Lecture at Florida State University, A portable spectrometer for nuclear forensics, April 15, 2004.

 

Jones, Paul

 

Jones, P.B.; Reynolds, J.L.; Brinson, R.G.; Butke, R.L. "Amine Mediated Photoreduction of Aryl Ketones in N-Heterocyclic Ionic Liquids: Novel Solvent Effects Leading to Altered Product Distribution." in Ionic Liquids as Green Solvents: Progress and ProspectsACS Symposium Series 856, Rogers, R.D.; Seddon, K.R. eds. pp. 370-381.  American Chemical Society, Washington, DC, 2003.

 

Reynolds, J.D.; Brinson, R.G.; Day, C.S.; Jones, P.B. "Highly Strained Dihydroanthraquinones: Oxidation vs. Elimination." Tetrahedron Lett., 2004, 45, 2955-2959.

 

Jones, P.B. "Globular Treasures Near Summer Showpieces." Sky and Telescope, September 2003, 111-116.

 

King, Bruce

 

Xu, X.; Cho, M.; Spencer, N. Y.; Patel, N.; Huang, Z.; Shields, H.; Kings, S. B.; Gladwin, M. T.; Hogg, N.; Kim-Shapiro, D. B. “Measurements of Nitric Oxide on the Heme Iron and -93 Thiol of Human Hemoglobin During Cycles of Oxygenation and Deoxygenation,” Proc. Natl. Acad. Sci. 2003, 100, 11303-11308.

 

Huang, Z.; Hearne, L.; Irby, C. E.; King, S. B.; Ballas, S. K.; Kim-Shapiro, D. B. “Kinetics of Increased Deformability of Deoxygenated Sickle Cells Upon Oxygenation,” Biophysical Journal, 2003, 85, 2374-2383.

 

Huang, J.; Zou, Z.; Kim-Shapiro, D. B.; Ballas, S. K.; King, S. B., “Hydroxyurea Analogs as Kinetic and Mechanistic Probes of the Nitric Oxide Producing Reactions of Hydroxyurea and Oxyhemoglobin,” J. Med. Chem., 2003, 46, 3748-3753.

 

Lockamy, V. L.; Huang, J.; Shields, H.; Ballas, S. K.; King, S. B.; Kim-Shapiro, “Urease Enhances the Formation of Iron Nitrosyl Hemoglobin in the Presence of Hydroxyurea,” Biochimica et Biophysica Acta 2003, 1622, 109-116..

 

Invited Participant in the Mesilla Workshop on the Chemistry of NO in Biological Signaling, Mesilla, NM, January 31-February 4, 2004.

 

Chemistry Department Seminar, North Carolina A&T University, December 4, 2003,

 

Biochemistry Department Seminar, Virginia Tech, September 22, 2003

 

Kondepudi, Dilip

 

Spontaneous Generation and Propagation of Chiral Asymmetry, Kondepudi, DK, International Journal of Quantum Chemistry, PD: 2004 VO: 98   PG: 222-227

 

Chiral symmetry-breaking transition in growth front of crystal phase of 1,1 -binaphthyl in its supercooled melt, Kouichi Asakura, Yasushi Nagasaka, Masashi Hidaka, Masato Hayashi, Shuichi Osanai, Dilip K. Kondepudi, Chirality  Volume 16, Issue 2, Date: 2004, Pages: 131-136

 

Invited seminars at: Tulane University, U. of Southern Missippii.

 

Lachgar, Abdou

 

Yan, M. B.; Zhou A.; Lachgar, A. “Octahedral niobium chloride clusters as building blocks of templated Prussian blue framework analogs,” Inorg. Chem. 2003, 42, 8818-8822.

 

Duraisamy, T.; Zhihua, Y.; Anokhina, E. V.; Choi, C. S.; Day, C. S.; Lachgar, A. “Layered niobium titanium oxychloride cluster compounds with six-member ring opening channels,” J. Solid State Chem. 2003, 175, 46-51.

 

T. Duraisamy, J. Qualls, A. Lachgar, “A2VNb6Cl18 (A = Rb, In, Tl): Synthesis, Crystal Structure and Magnetic Properties of a New Series of Quaternary Niobium Chloride Cluster Compounds” J. Solid State Chem. 2003, 170(2), 227-231.

 

Manderville, Richard

 

Dai, J.; Wright, M. W.; Manderville, R.A. “An Oxygen-Bonded C8-Deoxyguanosine Nucleoside Adduct of Pentachlorophenol by Peroxidase Activation: Evidence for Ambident C8 Reactivity by Phenoxyl Radicals” Chem. Res. Toxicol. 2003, 16, 817-821. 

 

Invited Seminar, DNA Adduction by Ochratoxin A and Other Chlorinated Phenols”, University of Maryland, College Park, April 2, 2004

 

Invited Seminar, “DNA Adduction by Chlorinated Phenols” Appalachian State University, Boone, NC, October 17, 2003.

 

Noftle, Ronald

 

Synthesis and structural characterization of 3-thienyl alkyl imides, Dai, J.; Day, C. S.; Noftle, R. E. Tetrahedron, 2003, 59, 9389-9397.

 

Stoichiometric Preference in Copper-promoted Oxidative DNA Damage by Ochratoxin A. Manderville, R. A.; Calcutt,  M. W.;  Dai, J.; Park, G.; Gilman, I. G.; Noftle, R. E.; Mohammed, A. K.; Dizdaroglu, M.; Roderiguez, H.;  Akman, S. A.  J. Inorganic Biochemistry, 2003, 95, 87-96.

 

An Efficient Method for the Synthesis of 3-Alkylthiophenes Bearing Functional Groups: Imides and Amides, Dai, J.; Noftle, R. E. Synthetic Metals, 2003, 139, 81-88.

 

Salam, Akbar

 

A. Salam, M. S. Deleuze, and J.-P. François, “Computational Study of the Structural and Vibrational Properties of Ten and Twelve Vertex Closo-Carboranes”, Chem. Phys. 286, 45-61 (2003).

 

A. Salam, “Comment on “A Simple Model for the Nonretarded Dispersive Force Between an  Electrically Polarizable Atom and a Magnetically Polarizable One””, Am. J. Phys. 71, 283 (2003).

 

Seminar  A. Salam, “Nonlinear Optical Response and Yield in the Femtosecond Photodesorption of CO from Cu/001 Surface: A Density Matrix Theory”, Invited Lecture to Chemical Physics Theory Group, Wake Forest University, Winston-Salem, NC 27109, 20 Feb, 2004.

 

Seminar  A. Salam, “Recent Theoretical Studies of Molecular Chirality”, Invited Departmental Seminar at Department of Biological and Chemical Sciences, University of the West Indies, Cave Hill Campus, PO Box 64, Bridgetown, Barbados, 10 Mar, 2004.

 

Seminar  A. Salam, “A Density Matrix Theory of the Nonlinear Optical Response and Yield in the Femtosecond Photodesorption of CO from Cu/001 Surface”, Invited Lecture to Physical Chemistry Division, Department of Biological and Chemical Sciences, University of the West Indies, Cave Hill Campus, PO Box 64, Bridgetown, Barbados, 12 Mar, 2004.

 

Swofford, Robert

 

Seminar “Studying Bond Strengths using overtone spectroscopy and Computational Models”, Chemistry Department Seminar, UNC-Wilmington, September, 2003

 

Welker, Mark

 

Preparation of an (Aquo)Cobaloxime 1,3-Dienyl Complex and Its Diels-Alder Reactions in Water and Organic Solvents.  Carmen J. Tucker, Mark E. Welker,* Cynthia S. Day, and Marcus W. Wright, Organometallics, 2004, 23, 2257-2262.

 

Departmental Seminar, University of Richmond, Richmond, VA 9/26/03.

 

 

II.   Papers and Presentations Presented at Professional Meetings

Alexander, Rebecca

 

Rebecca Alexander and Susan Walker: “Contributions of the tRNA core to methionyl-tRNA synthetase inter-domain communication” Nucleic Acids Gordon Conference

June 1-6 Newport, RI

 

Michael Budiman, Uli Bierbach, and Rebecca Alexander: “Transcriptional inhibition by novel DNA lesions” Symposium on RNA Biology: RNA Tool and Target, October 17-18 Research Triangle Park, NC

 

Susan Walker and Rebecca Alexander: “Contributions of the tRNA core to methionyl-tRNA synthetase inter-domain communication” Symposium on RNA Biology: RNA Tool and Target, October 17-18 Research Triangle Park, NC

 

Michael Budiman, Uli Bierbach, and Rebecca Alexander: “Transcriptional inhibition by novel DNA lesions” Southeastern Regional Meeting of the American Chemical Society (SERMACS) November 13-16 Atlanta.

 

Susan Walker and Rebecca Alexander: “Contributions of the tRNA core to methionyl-tRNA synthetase inter-domain communication” Southeastern Regional Meeting of the American Chemical Society (SERMACS) November 13-16 Atlanta.

 

Bierbach, Ulrich

 

U. Bierbach: DNA interactions of platinum-acridinylthiourea hybrid agents: Hijacking the classical anticancer metal into the minor groove. Presented at the 227th National Meeting of the American Chemical Society; Anaheim, March 28-April 1, 2004.

 

H. Baruah and U. Bierbach: Characterization of the coordinative-intercalative hybrid DNA binding mode of a platinum-acridinylthiourea anticancer agent. Presented at the 55th Southeast Regional Meeting of the American Chemical Society; Atlanta, GA, Nov. 16-19, 2003.

 

C. G. Barry and U. Bierbach: Detection and characterization of adenine adducts of a novel Pt-acridine anticancer agent. Presented at the 55th Southeast Regional Meeting of the American Chemical Society; Atlanta, GA, Nov. 16-19, 2003.

 

M. E. Budiman, R. W. Alexander and U. Bierbach: Inhibition of DNA processing enzymes by novel DNA lesions. Presented at the 55th Southeast Regional Meeting of the American Chemical Society; Atlanta, GA, Nov. 16-19, 2003.

 

Brown II, Bernard

 

Bernard A. Brown II1,2, Elizabeth Tran3, Xinxin Zhang3, and E. Stuart Maxwell31Department of Chemistry and 2Center for Structural Biology, Wake Forest University, Winston-Salem, NC 27109; 3Department of Molecular and Structural Biology, North Carolina State University, Raleigh, NC 27695.  “Structural and Functional Analysis of Archaeal sRNPs” (Poster) Presented at the Nucleic Acids Gordon Research Conference, June 1-6 2003, Salve Regina University, Newport, RI.

 

Bernard A. Brown II1,2, Elizabeth Tran3, Xinxin Zhang3, and E. Stuart Maxwell31Department of Chemistry and 2Center for Structural Biology, Wake Forest University, Winston-Salem, NC 27109; 3Department of Molecular and Structural Biology, North Carolina State University, Raleigh, NC 27695. “Structural and Functional Analysis of Archaeal sRNPs” (Poster) Presented at the Symposium on RNA Biology V:  RNA, Tool and Target, October 17–18, 2003, North Carolina Biotechnology Center, Research Triangle Park, NC. 

 

Jinming Huang, Bernard A. Brown II, and S. Bruce King “Potential Nitric Oxide Producing Reactions of E. Coli Ribonucleotide Reductase with Hydroxyurea” (Poster) Presented at the 10th Annual Meeting of the Society for Free Radical Biology and Medicine, November 20–24, 2003, Seattle, WA. 

 

Bernard A. Brown II, Jimmy Suryadi, and David V. Lieberman “TBA” (Poster) To be presented at the 9th Annual Meeting of the RNA Society, June 1-6, 2004, Madison, WI.

 

Hinze, Willie

 

“Overview of Microbe (Bacteria, Virus, Fungi, etc.) Separations by Chromatographic (HPLC) Means”, WL Hinze, B  Mattiasson, and M Endo, Sectional Meeting of AOAC, Philadelphia, PA, June 14, 2004

 

King, Angela

 

Science Outreach at a Liberal Arts College, published in Proceedings of the Fifth Annual Conference on K-12 Science Outreach from University Science Departments, Raleigh, NC,  Feb. 10-12, 2004.

 

King, Bruce

 

Huang, J.; Brown, B. A., II; King, S.B. “Potential Nitric Oxide Producing Reactions of E. coli Ribonucleotide Reductase with Hydroxyurea,” 10th Annual Meeting of the Society of Free Radicals in Biology and Medicine, Seattle, WA, November 20-24, 2003.

 

Yakubu, M.; Kim-Shapiro, D. B.; King, S.B. “Approaches to the Identification of Hydroxylamine and other Nitric Oxide Species from the Metabolism of Hydroxyurea,” 10th Annual Meeting of the Society of Free Radicals in Biology and Medicine, Seattle, WA, November 20-24, 2003.

 

Zou, Z.; King, S. B. "Carbohydrate-Derived N-Hydroxyureas as New Nitric Oxide Donors," Abstract of Papers, 226th National Meeting of the American Chemical Society, New York, NY, American Chemical Society, Washington, D.C., 2003, MED 324.

 

Allen, C. L.; King, S. B. "Development of an Improved Method for the Synthesis of Polyhydroxyureas," Abstract of Papers, 55th Southeast Regional Meeting of the American Chemical Society, Atlanta, GA, American Chemical Society, Washington, D.C. 2003, CHD.

 

Sha, X.; King, S. B. "Syntheses of hydroxamic acid based siderophore analogs as potential inhibitors of siderophore biosynthesis," Abstract of Papers, 227th National Meeting of the American Chemical Society, Anaheim, CA, American Chemical Society, Washington, D.C., 2004, MED 77.

 

Zou, Z.; King, S. B. "Water-soluble N-hydroxyureas as New Nitric Oxide Donors," Abstract of Papers, 227th National Meeting of the American Chemical Society, Anaheim, CA, American Chemical Society, Washington, D.C., 2004, MED 238.

 

Kondepudi, Dilip

 

Gordon Conferences on the Origin of Life, Invited Talk

 

Lachgar, Abdou

 

226th ACS National Meeting, September 7-11, 2003 (New York City): Synthesis and properties of molybdenum chloride cluster compounds with 14-membered hetero-macrocyclic transition metal complexes. Y. Zhao , C. Day , A. Lachgar.

 

Gordon Conference on Solid State Chemistry (II), September 14-19, 2003 Royal College, (Cambridge): Dimensional Reduction in Niobium Oxychloride Cluster Compounds: Synthesis and Crystal structure of Cs2InNb6Cl15O and its relationship with AxNb6Cl12O2. A. Lachgar

 

9th European Conference on Solid State Chemistry,  September 3rd – 6th, 2003 (Stuttgart): Dimensional Reduction in Niobium Oxychloride Cluster Compounds. A. Lachgar (Invited)

 

55th Southeast Regional Meeting of the American Chemical Society, November 16-19, 2003 (Atlanta,GA): “Interaction Between Octahedral Niobium Cyanochloride Clusters and Alkaline-Earth Metal Complexes” Yan, Z.; Day, C. S.; Lachgar, A.

 

55th Southeast Regional Meeting of the American Chemical Society, November 16-19, 2003 (Atlanta,GA): “Hybrid Inorganic-Organic Materials containing Metal-Cyanohalide Clusters” Yan, B.; Day, C. S.; Lachgar, A.

 

Manderville, Richard

 

Poster Presentation, J. Dai, A.L. Sloat, M.W. Wright, M.D. Adams, S.A. Akman, R.A. Manderville, “DNA Adduction and In Vitro Mutagenicity of Chlorophenols by Peroxidase Activation: Role of Ambident (O- vs. C-) Phenoxyl Radicals” ACS National Meeting, New York, N.Y. September 7-11, 2003.

 

Noflte, Ronald

 

Towards a synthesis of thiophene-based conducting polymers bearing hemilabile ligands, S. J. Howell, C. S. Day, and R. E. Noftle,  227th National American Chemiscal Society Meeting, Anaheim CA. March 28-April 1, 2004. Invited presentation by Div. Polymer Chemistry

 

Sixth International Symposium on Functional pi-Electron Systems, Ithaca, New York, June 13-18, 2004

 

Salam, Akbar

 

S. W. Paine and A. Salam, “Computational Study of Tautomerism in Hydroxycyclopropenone”. Abstract accepted and poster presented at 44th Sanibel Symposium on Atomic, Molecular, Biophysical and Condensed Matter Theory, St. Augustine, FL, 28 Feb – 5 Mar, 2004.

 

Swofford, Robert

 

“Using C-H and O-H overtone spectra to evaluate models of bond dissociation”, SouthEast Theoretical Chemists Association, annual meeting, Clemson University, May, 2003.

 

“C-H overtones and Computed potenetial energy surfaces: New insights into bond strengths”, SouthEast Regional Meeting of the American Chemical Society, Atlanta, November, 2003.

 

 

III.  Editorships, Offices, and Consultancies 

 

Bierbach, Ulrich

 

Guest Editor: Special issue “Metals in Disease and Therapy” of Current Topics in Medicinal Chemistry, Vol. 4, no. 15 (2004)  (Bentham Publishers)

 

Hinze, Willie

 

Editorial Board, Journal of Liquid Chromatography & Related Technologies

 

Editorial Board, Analytical Letters

 

Editorial Board, Talanta

 

Editorial Board, Journal of Undergraduate Chemical Research

 

Editorial Review Board (Analytical Sub-board), American Institute of Chemists

 

Jones, Bradley

 

Editorial Board of Applied Spectroscopy Reviews

 

Editorial Board of Microchemical Journal

 

King, Angela

 

Editorial Board, Interactive Multimedia Electronic Journal

 

King, S. Bruce

 

Guest Editor, Serial Review for Free Radicals in Biology and Medicine, “Recent Progress in Nitric Oxide Donation,” Spring 2004.

 

National Institutes of Health, Special Study Section-B (Member conflicts in Biophysics and Chemistry), November, 2003

 

American Heart Association Study Section Mid Atlantic/Pennsylvania Affiliate, April 2004

 

Kondepudi, Dilip

 

Editorial Board, of the journal Chirality

 

Consultant for George Group Consulting

 

Manderville, Richard

 

Editorial Board, Chemical Research in Toxicology

 

Noftle, Ronald

 

Visiting Associate, Committee on Professional Training, American Chemical Society

 

Consultant for Marshallton Laboratories (1 hr/mo)

 

Welker, Mark

 

Editorial Advisory Board, Letters in Organic Chemistry, Bentham Science Publishers

 

 

IV.  External Grants Received 

 

Alexander, Rebecca

Topic:

Acquisition of a Chemistry/Biology biomolecular imaging center

Agency:

NSF (Major Research Instrumentation)

$  Requested:

$139,258

$  Funded:

$42,295 (reduced amount due to overlap with NCBC grant)

 

Topic:

 Dissecting protein and nucleic acid contributions to efficient tRNA aminoacylation

Agency:

National Foundation for Cancer Research

$  Requested:

$147,200

$  Funded:

$100,000 (2 years at $50K/year)

 

 

Bierbach, Ulrich

Topic:

Novel DNA metalating hybrid anticancer agents

Agency:

National Institutes of Health/National Cancer Institute, R01 CA101880

$  Requested:

$223,716 (7/1/2003-6/30/2004)

$  Funded:

$223,716

 

 

Brown II, Bernard

Topic:

Structural investigation of archaeal ribosomal RNA modification systems

Agency:

American Cancer Society Institutional Research Grant

$  Requested:

$20,000

$  Funded:

$20,000

 

 

Jones, Bradley

Topic:

Faculty Recruitment Grant

Agency:

N.C. Biotechnology Grant

$  Requested:

$150,000

$  Funded:

$100,000

 

Topic:

A portable spectrometer for nuclear forensics

Agency:

NSF-Approaches to Combat terrorism

$  Requested:

$100,000

$  Funded:

$100,000

 

 

Jones, Paul

Topic:

"Visibly Caged Bio-Active Molecules and PDT."

Agency:

National Institute of Health (NIGMS)

$  Requested:

$215,530

$  Funded:

$215,530

 

 

King, Angela

Topic:

Science Outreach

Agency:

N.C. Biotech

$  Requested:

$4925

$  Funded:

$4925

 

 

King, S. Bruce

Topic:

The Nitric Oxide Producing Reactions of Hydroxyurea

Agency:

National Institutes of Health

$  Requested:

$900,000, direct/4 years

$  Funded:

$800.000 direct/4 years

 

 

Lachgar, Abdou

Topic:

Upgrade of a single crystal X-ray Diffractometer

Agency:

NSF

$  Requested:

117,500

$  Funded:

117,500

 

Topic:

Hybrid Inorganic-Organic Materials

Agency:

NSF

$  Requested:

127,000

$  Funded:

127,000