DEPARTMENT OF CHEMISTRY

FACULTY ACTIVITIES REPORT

FOR JULY 1, 2000 TO JUNE 30, 2001

• Publications, Performances, Exhibits
• Papers and Presentations
• Editorships, Offices, and Consultancies
• External Grants Received

I. Publications, Performances, Exhibits

Alexander, Rebecca W.

R.W. Alexander (2001) “Teasing apart the Taxol pathway” Trends Biochem. Sci.26: 152.

R.W. Alexander (2000) “Reducing (oxidative) stress: structure and mechanism” Trends Biochem. Sci. 25:643.

R.W. Alexander (2000) “A chiral attraction” Trends Biochem. Sci. 25, 427.

Bierbach, Ulrich

D. A. Sartori, B. Miller, U. Bierbach and N. Farrell: Modulation of the chemical and biological properties of transplatinum complexes. Monofunctional Transplatinum complexes containing one nucleobase as potential antiviral chemotypes. J. Biol. Inorg. Chem., 5:575-582 (2000).

U. Bierbach, M. Sabat, and N. Farrell: Inversion of the cis-geometry requirement for cytotoxicity in novel platinum(II) complexes containing the bidentate N,O-donor pyridine-2-yl-acetate (PyAc). Inorg. Chem., 39:1882-1890 (2000).

N. Farrell and U. Bierbach: Platinum complexes with anti-viral activity and method of using same. U.S. patent 6,113,934, Sep. 2000.

Colyer, Christa L.

C.L. Colyer, Capillary electrophoresis on chips. In: J. Cazes, Editor: Dekker Encyclopedia of Chromatography. Marcel Dekker, Inc., NY. Ch. 37, pp. 110-114 (June 2001).

C.L. Colyer, Noncovalent labeling of proteins in capillary electrophoresis with laser-induced fluorescence detection. Cell Biochem. Biophys. 33: 323-337, 2000.

C.L. Colyer, On-line quizzes facilitate preparedness for the general chemistry laboratory. In: D.G. Brown (Editor), Teaching With Technology; Anker Publishing, Bolton, MA, 2000 (pp. 90-94).

Hinze, Willie L.

Effect of a Variety of Organic Additives on Retention and Efficiency in Micellar Liquid Chromatography, S. Lopez-Grio, M. C. Garcia-Alvarez-Coque, W. L. Hinze, F. H. Quina, and A. Berthod, Analytical Chemistry, 72 (2000) 4826-4835.

Characterization of In Situ Generated Ionene Micellar Mimetic Stationary Phases for Liquid Chromatography, Julianne M. Braun and Willie L. Hinze, Analytical Letters, 33 (2000) 2983-2997.

Covalently Bound Ionene Polyelectrolyte-Silica Gel Stationary Phases for HPLC, Y. Suzuki, F. H. Quina, A. Berthod, R. W. Williams, M. Culha, I. U. Mohammadzai, and W. L. Hinze, Analytical Chemistry, 73 (2001) 1754-1765.

Fluorescence in Organized Assemblies, W. L. Hinze, in Encyclopedia of Analytical Chemistry, R. A. Meyers, Ed., John Wiley & Sons Ltd., Chichester, 2000, pp. 10364-10447.

Jones, Bradley T.

X. Hou, B.T. Jones, “Field Instrumentation in Atomic Spectroscopy,” Microchemical Journal, 2000, 66, 115-145.

X. Hou, B.T. Jones, “Inductively Coupled Plasma Optical Emission Spectroscopy,” in Encyclopedia of Analytical Chemistry, Robert A. Meyers, Ed., John Wiley & Sons Ltd., Chichester, 2000, pp. 9468-9485.

X. Hou, K.E. Levine, A. Salido, M. Ezer, S. Elwood, J.B. Simeonsson, B.T. Jones, “Tungsten Coil Devices in Atomic Spectrometry: Absorption, Fluorescence, and Emission,” Anal. Sci., 2001, 17, 175-180.

H.L. Peters, K.E. Levine, B.T. Jones, “An inductively coupled plasma carbon emission detector for aqueous carbohydrate separations by liquid chromatography,” Anal. Chem., 2001, 73, 453-457.

X. Hou, Z. Yang, B.T. Jones, “Determination of Se by Tungsten Coil Atomic Absorption Spectrometry using Ir as a Permanent Chemical Modifier,” Spectrochim. Acta Part B, 2001, 56, 203-214.

Jones, Paul B.

Parrish, N.P.; Houston, T.A.; Jones, P.B.; Townsend, C.A.; Dick, J.D., "In Vitro Activity of a Novel Antimycobacterial Compound, N-Octanesulfonylacetamide, and Its Effects on

Lipid and Mycolic Acid Synthesis." Antimicrob. Agents Chem., 2001, 45, 1143-1150.

Jones, P.B.; Parrish, N.M.; Houston, T.A.; Stapon, A.; Bansal, N.P.; Dick, J.D.;

Townsend, C.A., “A New Class of Anti-Tuberculosis Agents.” J. Med. Chem., 2000, 43,

3304-3314.

King, Angela G.

“The Use of Preclass Quizzes in Chemistry Classes,” Angela G. King and Yue-Ling Wong, in Teaching with Technology, David G. Brown, editor, Anker Publishing Company, Inc.: Bolton, MA, 2000.

King, S. Bruce

Ware, R. W., Jr.; King, S. B. "Evaluation of New L-Thiocitrulline Derivatives as Inhibitors of Nitric Oxide Synthase," Bioorganic and Medicinal Chemistry Letters, 2000, 10, 2779-2781.

Ware, R. W., Jr.; King, S. B. "P-Nitroso Phosphate Compounds: New N-O Heterodienophiles and Nitroxyl Delivery Agents," J. Org. Chem. 2000, 65, 8725-8729.

Xu, Y.; Alavanja, M.M.; Johnson, V.L.; Yasaki, G.; King, S.B. "Production of Nitroxyl (HNO) at Biologically Relevant Temperatures from the retro-Diels Alder Reaction of N-Hydroxyurea Derived Acyl Nitroso-9, 10-Dimethylantrhacene Cycloadducts," Tetrahedron Lett. 2000, 41, 4265-4269.

Kondepudi, Dilip

"Chemistry Far From Equilibrium" ( Co-Authors: G. Dewel and I. Prigogine) in New Chemistry, N. Hall (Ed) Cambridge Univ. Press, 2000

"Chirally Autocatalytic Reactions Performed in Highly Supersaturated Condition"

(Co-authors: Kouichi Asakura, , Kazuyuki Kurihara Akihito Ikumo Akiko Tanaka, Tomohito Miura, Takehiro Ozawa, Yoshinori Kushibe and Shuichi Osanai) Proceedings of the Symposium Macromolecular Symposium, 160 (2000) 7-13.

Lachgar, Abdessadek

Ekaterina V. Anokhina, Cynthia S. Day, and Abdessadek Lachgar, “A new layered niobium oxochloride cluster compound with novel framework topology”, Chem. Comm. 2000, 16 1491-1492.

Ekaterina V. Anokhina, Michael W. Essig, Cynthia S. Day, and Abdessadek Lachgar “Structural studies of indium and thallium insertion into the framework of the cluster compound Ti₂Nb₆Cl₁₄O₄”, Inorg. Chem. 2000, 39: (10) 2185-2188.

T. Xuejiao, M. Gentiletti, V. A. Morozov, B. I. Lazoryak, and A. Lachgar, “The Pillared Layered Framework of Ba₃(In_1-xM_x)₂(HXO₄)₆ (0 £ x £ 1; M=Fe, Cr; X = P, As): Synthesis, Crystal Structure, Thermal Stability and Mössbauer Spectroscopy”, Solid State Sciences, 2000, 3 (1-2) 143-153

Manderville, Richard A.

Melvin, M. S.; Tomlinson, J. T.; Saluta, G. R.; Kucera, G. L.; Lindquist, N.; Manderville, R. A. “Double-Strand DNA Cleavage by Copper·Prodigiosin” J. Am. Chem. Soc. 2000, 122, 6333-6334.

Welker, Mark E.

Preparation and Subsequent Reaction Chemistry of Cyclopentadienyl Molybdenum Dicarbonyl h³-2-Alkylidene Cyclobutanonyl Complexes. N. Ariane Vinson, Cynthia S. Day and Mark E. Welker*, Organometallics, 2000, 19, 4356.

Structure-Activity Relationships for Growth Inhibition and Induction of Apoptosis by 4-Hydroxy-2-nonenal in Raw 264.7 Cells. Robin L. Haynes, Luke Szweda, Kerry Pickin, Mark E. Welker and Alan J. Townsend, Molecular Pharmacology, 2000, 58, 788.

Advances in Cycloaddition. Volume 6 Edited by Michael Harmata (University of Missouri-Columbia). JAI Press: Stamford, CT. 1999. X + 250 pp. $115.00. ISBN 0-7623-0531-2. Mark E. Welker (Book Review). J. Am. Chem. Soc. 2000, 122, 5232.

Reactions of Cobaloximes with Alkenyl Triflates and Halides as a New Method for the Preparation of Cobalt-sp² Carbon Bonds. Kerry A. Pickin and Mark E. Welker*, Organometallics, 2000, 19, 3455.

Preparation of Cobaloxime Substituted Unsaturated Carbonyl Compounds and Their Subsequent Conversion into 1-Cobaloxime Substituted 1,3-Dienyl Complexes. Brittany L. Hayes, Torrey A. Adams, Kerry A. Pickin, Cynthia S. Day, and Mark E. Welker*, Organometallics, 2000, 19, 2730.

II. Papers and Presentations Presented at Professional Meetings

Bierbach, Ulrich

C. F. Bizzell and U. Bierbach: Development of Novel Iron Chelating Agents. Regional ACS Meeting, New Orleans, December 2000.

C. L. Rector and U. Bierbach: Determination of DNA Binding Modality of Acidinyl Thioureas by Use of Competition Titrations and Thermal Melting. Regional ACS Meeting, New Orleans, December 2000.

E. T. Martins, G. Saluta, H. Baruah, J. Kramarczyk, C. S. Day, G. L. Kucera and U. Bierbach: Synthesis, Characterization, and Biological Activity of Acridin-9-yl Thioureas And Some Platinum Conjugates. Regional ACS Meeting, New Orleans, December 2000.

J. Kramarzcyk, E. C. Turney, C. S. Day and U. Bierbach: Design of DNA-Targeted Photoactive Rhodium(III) Ammines for Biological Applications. Regional ACS Meeting, New Orleans, December 2000.

H. Baruah, S. M. Monnier, A. E. Belflower and U. Bierbach: DNA Binding of Acridin-9-yl Thioureas and Their Platinum Conjugates. Regional ACS Meeting, New Orleans, December 2000.

Colyer, Christa L.

C.L. Colyer, Using lasers to determine proteins in capillary electrophoresis. (Invited seminar) 18^th Triangle Chromatography Symposium and Instrument Exhibit, Raleigh, NC (May 2001)

C.L. Colyer, Protein determination by capillary electrophoresis with laser-induced fluorescence detection. (Invited seminar) North Carolina Agricultural & Technical State University, Greensboro, NC (Mar. 2001)

C.L. Colyer, Natively- and non-natively fluorescent protein determination by capillary electrophoresis. (Invited seminar) North Carolina State University, Raleigh, NC (Nov. 2000).

P.J. Viskari and C.L. Colyer, The determination of phycobiliproteins by capillary electrophoresis with laser-induced fluorescence detection. (Contributed seminar) 11^th Annual Frederick Conference on Capillary Electrophoresis, Frederick, MD (Oct. 2000).

Deborah Allen and C.L. Colyer, Teaching cases using cooperative learning techniques. (Invited seminar) Annual Conference on Case Study Teaching in Science, State University of New York at Buffalo (Oct. 2000).

Juliette Lantz and C.L. Colyer, Case studies in the disciplines: physical sciences. (Invited seminar) Annual Conference on Case Study Teaching in Science, State University of New York at Buffalo (Oct. 2000).

C.L. Colyer, Cases used in general chemistry, and, Teaching cases by the jigsaw method. (Invited seminar) Case Studies in Science Workshop, State University of New York at Buffalo (June 2000).

Hinze, Willie L.

Evaluation of Unusual Chiral Selectors for Optical Resolutions, presented at the joint Southeast/Southwest Regional American Chemical Society Meeting, December 6, 2000, New Orleans, LA

The Wide, Wonderful World of Cyclodextrins, presented at the annual North Carolina Institute of Chemists Meeting, April 7, 2001, Davidson, NC.

Jones, Bradley T.

B.T. Jones, “A Carbon Emission Detector for HPLC,” Seminar Presentation, Department of Chemistry, Davidson College, Davidson, NC, Friday, February 23, 2001.

King, Angela G.

Use of Electronic Pre-class Quizzes to Increase Student Preparation in General and Organic Chemistry, National American Chemical Society Meeting; Washington, D.C., August 24, 2001.

King, S. Bruce

Li, X.; King, S.B. “Synthesis and Evaluation of New L-Canavanine Derivatives as Substrates and Inhibitors of Nitric Oxide Synthase,” Gordon Research Conference on Nitric Oxide, Ventura, CA, February 4-9, 2001.

Ware, R. W. Jr.; King, S.B. "Examining the Stereoselectivity of N-Phosphinoylnitroso Compound Cycloadditions," Abstract of Papers, 220^th National Meeting of the American Chemical Society, Washington, D.C., American Chemical Society, Washington, D.C. 2000, ORGN 558.

Lachgar, Abdessadek

A. Lachgar, E. Anokhina, “Design and Preparation of Low-dimensional Cluster Materials”, Joint Southeast Southwest ACS Meeting, Symposium on Crystal Engineering, New Orleans, Dec. 6-8, 2000.

A. Lachgar, “Metal Clusters in Titanium Niobium Oxychlorides”, Gordon Research Conferences on Solid state Chemistry, Colby-Sawyer College, New London, NH, July 30 - August 4, 2000.

A. Lachgar, “Chemistry of Niobium Oxychloride Cluster Compounds”, University of Rennes, Host: Prof. Christianne Perin, June 22, 2000

Ekaterina Anokhina, Charlotte T. S. Choi, Cynthia S. Day, Hyungrak Kim, Susan M. Kauzlarich, and Abdessadek Lachgar, “New Niobium Oxychloride Cluster Compounds with NovelI Intercluster Connectivity”, Joint Southeast Southwest ACS Meeting, New Orleans, Dec. 6-8, 2000.

E. Anokhina, C. Choi, C. Day, A. Lachgar, “Niobium Cluster Oxochloride Compounds with a Novel Intercluster Connectivity: M₂Nb₆Cl₁₂O₂ (M = Rb, In, Cs)”, Gordon Research Conferences on Solid state Chemistry, Colby-Sawyer College, New London, NH, July 30 - August 4, 2000

Charlotte T. S. Choi, Cynthia S. Day, Yves Piffard, and Abdou Lachgar, “A Novel Indium Phosphate-Oxalate Hybrid Open-Framework Compound”, Joint Southeast Southwest ACS Meeting, New Orleans, Dec. 6-8, 2000.

Abdou Lachgar, Charlotte T.S. Choi, Ekaterina Anokhina, Cynthia S. Day, “A Novel Open-Framework Hybrid Organic-Inorganic Gallium Phosphate –Oxalate”, Joint Southeast Southwest ACS Meeting, New Orleans, Dec. 6-8, 2000.

Manderville, Richard A.

Invited Seminar, “Double-Strand DNA Cleavage by Copper·Prodigiosin” University of North Carolinia, Willmington, March 2, 2001.

Invited Seminar, “Double-Strand DNA Cleavage by Copper·Prodigiosin” Pacifichem 2000 Symposium 101: DNA and RNA Cleavage. Invited by Dr. James K. Bashkin, Monsanto Company, St. Louis, MO 63167 USA.

Poster Presentation, J.T. Tomlinson, G. Park, R.A. Manderville, “The Metal Coordination of Prodigiosin: Providing Insight to the Double-Strand DNA Cleavage Event” 52^nd Southeast/56^th Southwest Combined Regional Meeting of the American Chemical Society, New Orleans, Louisiana, December 6-8, 2000.

Seminar, Matt S. Melvin and Richard A. Manderville, “Synthesis, Structure-Activity Relationships, and Biological Activity of Prodigiosin Based Anticancer Compounds” 52^nd Southeast/56^th Southwest Combined Regional Meeting of the American Chemical Society, New Orleans, Louisiana, December 6-8, 2000.

Seminar, M.W. Calcutt, R.A. Manderville and R.E. Noftle, “The Mechanism of Toxicity of Fungal Metabolite Ochratoxin A: Providing Insight Using Electrochemical Techniques” 52^nd Southeast/56^th Southwest Combined Regional Meeting of the American Chemical Society, New Orleans, Louisiana, December 6-8, 2000.

Noftle, Ronald E.

Synthesis and Characterization of Fluorinated Thiophene Imides and Amides, J. Dai, J. Sellers, N. Fustino, and R. E. Noftle, 15^th Winter Fluorine Conference, St. Petersburg, Fl. Jan. 13-19, 2001. International.

Preparation and Properties of New Thiophene Monomers Containing Functional Groups, J. Dai and R. E. Noftle, SE/SW Reg. ACS Meeting, New Orleans, Dec. 6-9, 2000.

Electrochemistry of Ochratoxin A, W. Calcutt, R. E. Noftle, and R. A. Manderville, SE/SW Reg. ACS Meeting, New Orleans, Dec. 6-9, 2000.

Invited Research Seminar at Dept. Chemistry, Appalachian State Univ., Sept. 2000.

Welker, Mark E.

Program Officer Seminar, National Science Foundation, Washington, DC, 12/12/00.

Inorganic Seminar, UNC-CH, Chapel Hill, NC, 11/28/00.

III. Editorships, Offices, and Consultancies

Hinze, Willie L.

Served on the Editorial Board of the Journal of Liquid Chromatography & Related Technologies

Served on the Editorial Board of Talanta

Served on the Editorial Board of Analytical Letters

Jones, Bradley T.

Served as grant proposal review panelist for the Environmental Protection Agency – Small Business Innovative Research Program (Measurement and Monitoring section), August 28-30, 2000, Washington DC.

Served as grant proposal review panelist for the Environmental Protection Agency – Small Business Innovative Research Program (Measurement and Monitoring section), June 12-14, 2001, Washington DC.

Consultant, Leeman Labs, Inc., Hudson, NH

King, Angela G.

Member Editorial Board, Interactive Multimedia Electronic Jounal of Computer-Enhanced Learning, 1997-present.

Consultant, Educational Testing Services, Fall 2000 (<10 hours)

Consultant, McGraw-Hill Higher Education, Spring 2001 (<10 hours)

Kondepudi, Dilip

Member of the editorial board of Chirality

Noftle, Ronald E.

Alternate Councilor and Member of Executive Committee, Division of Fluorine Chemistry, American Chemical Society, National

Visiting Associate of the Committee on Professional Training, American Chemical Society, National

Consultant, Marshallton Research Laboratories (one hour per month)

IV. External Grants Received

Alexander, Rebecca W.

$55,000 “Mirror-image inhibitors of an essential bacterial protein,” North Carolina Biotechnology Center.

Bierbach, Ulrich

$55,000 “Photochemistry and Photobiology of Novel DNA-targeted Light-activatable Rhodium(III) Ammine Compounds,” North Carolina Biotechnology Center.

Colyer, Christa L.

$25,000 “Relative importance of electrostatic and hydrophobic interactions between model proteins and near-IR polymethine dyes.” American Chemical Society - Petroleum Research Fund, Type G award.

$566,184 “Development of a bili-microchip-analyzer: Shipboard determination of phycobiliproteins in ocean water samples.” National Science Foundation - OTIC program

Jones, Bradley T.

$15,000 “Development of a Tungsten Coil Spectrometer.” Leeman Labs, Inc.

Jones, Paul B.

$55,000 “A General Strategy for Photoactivation of Enzymes Using Visible Light,” North Carolina Biotechnology Center.

King, Angela G.

$25,000 “Revitalizing the Chemistry Program’s First Two Years.” The Camille and Henry Dreyfus Foundation Special Program in Chemical Sciences.

King, S. Bruce

$66,500 Fructose Derived N-Hydroxyureas as Novel Therapeutic Agents for Breast Cancer." Department of the Army

$300,000 “Synthesis and Evaluation of L-Arginine Derivatives as Mechanistic Probes of Nitric Oxide Synthase.” American Heart Association.

Kondepudi, Dilip

$21,000 “Collaborative Research in Japan.” Japan Society for Promotion of Science.

Lachgar, Abdessadek

$60,000 Preparation and Characterization of Low-Dimensional and Open-Framework Cluster Materials. American Chemical Society/Petroleum Research Fund (ACS/PRF).

Manderville, Richard A.

$110,000 “Acquisition of an LC/MS,” North Carolina Biotechnology Center

Swofford, Robert L.

$75,000 “2000 Technology Literacy Challenge Grant.” NC Dept of Public Instruction.

Welker, Mark E.

$254,000 “NSF Renewal Grant.” NSF.

$16,000 “ROA Supplement.” NSF.