LIFE-P
Lifestyle Interventions and Independence For Elders-Pilot

Sponsor:
NIA

Rejeski
Katula
Marsh
Brubaker

The major goal of this project is to gather preliminary data that will determine the feasibility of conducting a Phase 3 randomized, controlled trial (RCT) that will provide definite evidence in the use physical exercise to prevent physical and mobility disability in older persons.

Data collection completed; Analyses ongoing;
Main trial under review at NIA

Katula et al. (2007)

Groessl et al. (2007)

The LIFE Study Investigators (2006)

Rejeski et al. (2005)

LookAHEAD
Action for Health in Diabetes

Sponsor:
NIDDK

Rejeski
Miller
Ribisl

Look AHEAD is a multicenter randomized clinical trial to examine the effects of a lifestyle intervention designed to achieve and maintain weight loss over the long term through decreased caloric intake and exercise. It is focused on the disease most affected by overweight and obesity, type 2 diabetes, and on the outcome that causes the greatest morbidity and mortality, cardiovascular disease.

Data Collection Ongoing; analyses ongoing.

Rejeski et al. (2006).

Wadden et al. (2006)

Ribisl et al. (2007) Jul 20;

PEPC
Prenatal Exposures/ Postnatal Events:  Antenatal Steroids and Blood Pressure in Childhood

Sponsor:
NICHD

Nixon

The major goal of this project is to examine the effects of antenatal steroid exposure on blood pressure levels and mechanisms of blood pressure regulation in adolescents born prematurely with very low birth weight

Data collection ongoing

Nixon et al. (2007)

Washburn et al. (2006)

O’Shea et al. (2007)

REACT II
Reconditioning Exercise And COPD Trial II

Sponsor:
NHLBI

Berry
Rejeski
Katula

The goal of this project is to compare traditional short-term exercise therapy to a theoretically-driven lifestyle activity intervention on long-term maintenance of physical activity in persons with COPD.

Data Collection Completed; Analyses Ongoing

Berry (2007)

Berry et al. (2006)

Foy et al. (2006)

BASS
Be A Smart Shopper

Sponsor:
Pro Humanitate Fund

Miller

The goal of this project is to examine the impact of a novel supermarket led nutrition education program on knowledge and behaviors in grade school children

Data Collection Ongoing

CLIP
Cooperative Lifestyle Intervention Program

Sponsor:
NHLBI

Rejeski
Brubaker

CLIP is examining the effect of physical activity only, a combination of physical activity and weight loss, or successful aging education on mobility disability. We are currently recruiting adults 60-79 years of age who are overweight and have a history of cardiovascular disease or the metabolic syndrome to participate.

Data Collection Ongoing

DCIS
A Pilot Study in Women with Ductal Carcinoma in Situ

Sponsor:
Piedmont Alliance for Cancer Research and Education Fund

Mihalko

The purpose of this study is to describe the physical functioning and health-related quality of life (HRQL) of women recently treated for DCIS and to determine if a moderate, tailored exercise intervention, as compared to enhanced usual care, significantly improves physical outcomes, including cardiorespiratory endurance, muscular strength and flexibility, and HRQL in women with DCIS. In addition, this study will make possible a comparison of DCIS participants with women diagnosed with stage I-III breast cancer who have been recruited for our larger prospective trial to describe differences in outcome measures by severity of diagnosis, as well as differential effect of the exercise intervention.

Data collection completed; Analyses ongoing

HELP PD
Healthy Living Partnership to Prevent Diabetes

Sponsor:
NIDDK

Katula

The overall goal is to translate knowledge regarding the prevention of type 2 DM into practice in the community.  This project is testing the effectiveness of a group-based intensive lifestyle behavioral intervention led by community health workers delivered in the community via an existing Diabetes Care Center (DCC) in preventing the onset of type 2 DM.

Data Collection Ongoing

HF ACTION
Heart Failure:  A Controlled Trial Investigating Outcomes In Heart Failure

Sponsor:
NIH

Brubaker

The major goal of this large, multicenter trial is to determine if exercise training reduces the morbidity and mortality associated with heart failure

Baseline data collection completed and analyses ongoing; Outcome analyses will begin spring 2008.

IDEA Intensive Diet and Exercise for Arthritis

Sponsor:
NIAMS

Messier
Mihalko
Miller

The primary aim is to compare the effects of intensive diet and exercise, both alone and in combination, on potential mechanisms associated with the OA disease pathway, inflammation and knee joint loads.  Secondary aims are: to compare the effects of these interventions on self-reported function and pain, and mobility; to determine the dose response to weight loss on disease progression; to determine if inflammatory biomarkers and knee joint loads significantly effect function, pain, and disease progression; and to determine the association between quadriceps strength and disease progression as a function of knee alignment.

Data Collection Ongoing

LIFE
Accelerometer Lifestyle Interventions and Independence For Elders – Substudy of Accelerometry

Sponsor:
NIA

Miller

The goal of this project is to determine if a movement sensor, the Actigraph accelerometer, can document a difference in the amount of physical activity, especially walking, performed by participants assigned to the exercise intervention versus the healthy aging class after 6 months in the LIFE study. 

Data Collection Completed; Analyses ongoing

LOSE IT
Laparoscopic Obesity Surgery

Sponsor:
Pepper Pilot Project

Miller

The goal of this observational study is to examine the impact of extreme weight loss for 1 year following laparoscopic Roux-en-Y gastric bypass surgery on inflammation, physical function, and body composition

Data Collection Ongoing

RESET
Restoration of Chronotropic Competence in Heart Failure Patients with Normal Ejection Fraction

Sponsor:
Boston -Scientific

Brubaker

Core-laboratory for cardiopulmonary exercise testing outcomes from multi-center trial

Recruitment and randomization to begin Jan. 08

RESTOREResearch on Optimal Recovery Practices in Breast Cancer

Sponsor:
Department of Defense

Mihalko
Ribisl

The purpose of this study is to examine the influence of an exercise intervention on physical and psychosocial health outcomes in breast cancer survivors.  Specifically, intervention effects on self-efficacy, quality of life and functional outcomes will be determined. Additionally, adherence to the physical activity program will be examined at 18-months of follow-up.

Data collection completed; Analyses ongoing

SHARP-P
Senior Health and Activity Research Program-Pilot

Sponsor:
NIA

Rejeski
Katula

The goal of the project is to develop and conduct a randomized clinical trial to assess whether a multi-factorial intervention involving physical activity and cognitive training reduces the risk of significant cognitive decline in older individuals.

Recruitment and Randomization to begin in 2008

WAKE
Women, Arthritis, Adkipokines and Obesity Study

Sponsor:
WFU Science Research Fund

Miller

The goal of this study is to measure body composition, concentrations of leptin, adiponectin, and leptin soluble receptor in normal weight and obese older women with and without knee OA. 

Data Collection Ongoing