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Description of Research
Iron and sulfur atoms can form chemical structures of biological importance named [Fe-S] clusters.  The importance of Fe-S clusters is intimately associated with the essential role of Fe-S proteins in a wide range of life sustaining processes including respiration, carbon metabolism, photosynthesis and nitrogen fixation.  These chemical structures are organized in fundamental units of [2Fe-2S] and [4Fe-4S] clusters, or multimers, or fragments of these units.  Although [Fe-S] clusters can be formed in vitro from their toxic individual components, almost all forms of life have developed specialized machineries dedicated to the assembly of these metal-centers.  Our research group is interested in understanding the biochemical formation of [Fe-S] clusters in Gram-positive bacteria.. --READ MORE--