Courses Taught
Microbiology, Genetics, Biochemistry, Molecular
Biology, Microbial Pathogenesis and various graduate seminars in the molecular
biosciences including gene expression, protein synthesis, the molecular
biology of RNA, "molecular fossils," and molecular modeling.
I also teach freshman seminars; one on the human genome, another on
how biological and geographical factors have influenced human history, and a third on social and economic issues facing humanity in the 21st century.
Selected Publications
Sanders, C.L., Lohr, K.J., Gambill, H.L, Curran, R.B. and Curran, J.F. 2008. Anticodon loop mutations perturb reading frame maintenance by the E site tRNA. RNA, 1874-1881.
Sanders, C.L. and Curran, J.F. 2007. Genetic analysis of the E site during RF2 programmed frameshifting. RNA 13, 1483-1491..
Lim, V.I., Curran, J.F. and Garber, M. 2005. Ribosomal elongation cycle: Energetic, Kinetic and Stereochemical aspects, Journal of Molecular Biology 351: 470-480.
Curran, J.F. 2003. Death,
Taxes, and the Genetic Code? Chemistry & Biology 10:1-2.
Lim, V.I. and Curran,
J.F. 2001. Analysis of Codon:Anticodon Interactions within the Ribosome
Provides New Insights into Codon Reading and the Genetic Code Structure.
RNA 7: 942-957.
Wu,
L., and Curran, J.F. 1999. An allosteric
synthetic DNA. Nucleic Acids Research 27: 1512-1516.
Tsai, F., and Curran,
J.F. 1998. tRNA2Gln mutants that translate
the CGA arginine codon as glutamine in Escherichia coli.
RNA 4: 1514-1522.
Curran,
J.F. 1998. Modified Nucleosides in Translation, chapter 27 in Modification
and Editing of RNA: The Alteration of RNA Structure and Function,
H. Grosjean, and R. Benne, eds. American Society for Microbiology Press,
pp. 493-516.
Qian,
Q., Curran, J.F., and Bjork, G.R. 1998. The N6-methyl group of the
modified nucleoside N6-methyl-N6-threonylcarbamoyladenosine (m6t6A) in
transfer RNA of Escherichia coli improves translational efficiency,
Journal of Bacteriology 180: 1808-1813.
Li,
J.-n., Esberg, B, Curran, J.F., and Bjork, G.R. 1997. Three modified
nucleosides present in the anticodon stem and loop influence the in
vivo aa-tRNA selection in a tRNA-dependent manner. Journal of Molecular
Biology 271: 209-221.
Schwartz, R. and Curran, J.F.
1997. Analyses of frameshifting at UUU-pyrimidine sites, Nucleic Acids
Research 25, 2005-2011.
Curran, J.F. 1995. Decoding
with the A:I base pair is inefficient. Nucleic Acids Research 23,
683-688.
Curran, J.F. 1993. Analysis of effects of tRNA:message stability on frameshift frequency at the Escherichia coli RF2 programmed frameshift site. Nucleic Acids Research 21, 1837-1843.
Curran, J.F. and Yarus, M. 1987. Reading frame selection and tRNA anticodon loop stacking. Science 238, 1545-1550.
Recent Op-Ed Articles:
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